Afamin

Definition:

Functions as carrier for hydrophobic molecules in body fluids (Probable). Essential for the solubility and activity of lipidated Wnt family members, including WNT1, WNT2B, WNT3, WNT3A, WNT5A, WNT7A, WNT7B, WNT8, WNT9A, WNT9B, WNT10A and WNT10B. Binds vitamin E. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the transport of vitamin E across the blood-brain barrier.

References:

[1]. Andreas F Voegele, et al. Characterization of the vitamin E-binding properties of human plasma afamin. Biochemistry. 2002 Dec 10;41(49):14532-8. [Content Brief]

[2]. Emiko Mihara, et al. Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin. Elife. 2016 Feb 23;5:e11621. [Content Brief]

[3]. Lidija Jerkovic, et al. Afamin is a novel human vitamin E-binding glycoprotein characterization and in vitro expression. J Proteome Res. 2005 May-Jun;4(3):889-99. [Content Brief]

[4]. Ingrid Kratzer, et al. Afamin is synthesized by cerebrovascular endothelial cells and mediates alpha-tocopherol transport across an in vitro model of the blood-brain barrier. J Neurochem. 2009 Feb;108(3):707-18. [Content Brief]

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