African trypanosomiasis

Definition:

African trypanosomiasis is a parasitic disease affecting both humans and livestock. It is one of the most common serious protozoan infections in sub-Saharan Africa, especially in areas of conflict. Its causative agent is Trypanosoma brucei, whose protein has been shown to induce apoptosis in human brain.

References:

[1]. Jonathan K Stiles, et al. Trypanosome apoptotic factor mediates apoptosis in human brain vascular endothelial cells. Mol Biochem Parasitol. 2004 Feb;133(2):229-40. [Content Brief]

[2]. Peter J Hotez, et al. Neglected tropical diseases in sub-saharan Africa: review of their prevalence, distribution, and disease burden. PLoS Negl Trop Dis. 2009 Aug 25;3(8):e412. [Content Brief]

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