AL amyloidosis

Definition:

Immunoglobulin light chain (AL) amyloidosis is the most common form of systemic amyloidosis. AL amyloidosis is a disorder of plasma cells or less commonly B cells that produce misfolded immunoglobulin light chain that deposits in tissues of a variety of organs causing organ dysfunction. Commonly affected organs include the heart, kidney, liver, soft tissues, peripheral and/or autonomic nerves, and the gastrointestinal tract.

References:

[1]. Giampaolo Merlini, et al. AL amyloidosis: from molecular mechanisms to targeted therapies. Hematology Am Soc Hematol Educ Program. 2017 Dec 8;2017(1):1-12. [Content Brief]

[2]. M Hasib Sidiqi, et al. Daratumumab for the treatment of AL amyloidosis. Leuk Lymphoma. 2019 Feb;60(2):295-301. [Content Brief]

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