Aldehyde dehydrogenase family 3 member A2

Definition:

Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.

References:

[1]. N M Verhoeven, et al. Involvement of microsomal fatty aldehyde dehydrogenase in the alpha-oxidation of phytanic acid. FEBS Lett. 1998 Jun 16;429(3):225-8. [Content Brief]

[2]. Robert-Jan Sanders, et al. Characterization of the human omega-oxidation pathway for omega-hydroxy-very-long-chain fatty acids. FASEB J. 2008 Jun;22(6):2064-71. [Content Brief]

[3]. Markus A Keller, et al. A gatekeeper helix determines the substrate specificity of Sjögren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase. Nat Commun. 2014 Jul 22;5:4439. [Content Brief]

[4]. Kanae Nakahara, et al. The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway. Mol Cell. 2012 May 25;46(4):461-71. [Content Brief]

[5]. Matthew D Lloyd, et al. Characterisation of recombinant human fatty aldehyde dehydrogenase: implications for Sjögren-Larsson syndrome. J Enzyme Inhib Med Chem. 2007 Oct;22(5):584-90. [Content Brief]

[6]. T L Kelson, et al. Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization. Biochim Biophys Acta. 1997 Apr 17;1335(1-2):99-110. [Content Brief]

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