ALK and LTK ligand 2

Definition:

Cytokine that acts as a physiological ligand for receptor tyrosine kinases LTK and ALK, leading to their activation. Cytokine-binding is sufficient to activate LTK. In contrast, ALKAL2-driven activation of ALK is coupled with heparin-binding to ALK. Stimulation of ALK signaling is involved in neural development and regulation of energy expenditure.

References:

[1]. Jikui Guan, et al. FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase. Elife. 2015 Sep 29;4:e09811. [Content Brief]

[2]. Steven De Munck, et al. Structural basis of cytokine-mediated activation of ALK family receptors. Nature. 2021 Dec;600(7887):143-147. [Content Brief]

[3]. Andrey V Reshetnyak, et al. Mechanism for the activation of the anaplastic lymphoma kinase receptor. Nature. 2021 Dec;600(7887):153-157. [Content Brief]

[4]. Marcus Borenäs, et al. ALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK mutation. EMBO J. 2021 Feb 1;40(3):e105784. [Content Brief]

[5]. Andrey V Reshetnyak, et al. Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-α). Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):8340-8345. [Content Brief]

[6]. Andrey V Reshetnyak, et al. Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions. Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15862-7. [Content Brief]

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