Allograft inflammatory factor 1

Definition:

Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.

References:

[1]. Jörg O Schulze, et al. Structural and functional characterization of human Iba proteins. FEBS J. 2008 Sep;275(18):4627-40. [Content Brief]

[2]. Xing Chen, et al. AIF-1 expression modulates proliferation of human vascular smooth muscle cells by autocrine expression of G-CSF. Arterioscler Thromb Vasc Biol. 2004 Jul;24(7):1217-22. [Content Brief]

[3]. Sheri E Kelemen, et al. Expression of allograft inflammatory factor-1 in T lymphocytes: a role in T-lymphocyte activation and proliferative arteriopathies. Am J Pathol. 2005 Aug;167(2):619-26. [Content Brief]

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