Alopecia universalis

Definition:

Alopecia universalis is the most severe form of alopecia areata, characterized by generalized scalp and body atrichia with papular lesions. Mutations in the gene HR coding for the Hairless protein are associated with alopecia universalis. It is inherited in autosomal recessive manner.

References:

[1]. S Cichon, et al. Cloning, genomic organization, alternative transcripts and mutational analysis of the gene responsible for autosomal recessive universal congenital alopecia. Hum Mol Genet. 1998 Oct;7(11):1671-9. [Content Brief]

[2]. W Ahmad, et al. Alopecia universalis associated with a mutation in the human hairless gene. Science. 1998 Jan 30;279(5351):720-4. [Content Brief]

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