Alpha-Galactosidase A (α-Gal A)

Definition:

Alpha-Galactosidase A (α-Gal A) is a soluble lysosomal enzyme that hydrolyzes the terminal alpha-galactosyl moiety from glycolipids and glycoproteins. The predominant lipid hydrolyzed by α-Gal A is ceramide trihexoside, also known as globotriaosylceramide or Gb3.

References:

[1]. Nelson MP, et al. Autophagy-lysosome pathway associated neuropathology and axonal degeneration in the brains of alpha-galactosidase A-deficient mice. Acta Neuropathol Commun. 2014 Feb 14;2:20. [Content Brief]

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