Aminoimidazole carboxamide ribotide (AICAR)

Definition:

Aminoimidazole carboxamide ribotide (AICAR) is a purine biosynthetic intermediate and a substrate of the AICAR transformylase/IMP cyclohydrolase (PurH) enzyme in Salmonella enterica. Aminoimidazole carboxamide ribotide (AICAR) accumulates and indirectly inhibits synthesis of the essential coenzyme thiamine pyrophosphate (TPP).

References:

[1]. Bazurto JV, et al. Untargeted metabolomics confirms and extends the understanding of the impact of aminoimidazole carboxamide ribotide (AICAR) in the metabolic network of Salmonella enterica. Microb Cell. 2017 Nov 22;5(2):74-87. [Content Brief]

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