Ankyrin-3

Definition:

In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption.; [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin.

References:

[1]. Stephanie Bechtel, et al. The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [Content Brief]

[2]. Pedro San-Cristobal, et al. Ankyrin-3 is a novel binding partner of the voltage-gated potassium channel Kv1.1 implicated in renal magnesium handling. Kidney Int. 2014 Jan;85(1):94-102. [Content Brief]

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