Ankyrin repeat and KH domain-containing protein 1

Definition:

May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases.

References:

[1]. Melissa C Miles, et al. Molecular and functional characterization of a novel splice variant of ANKHD1 that lacks the KH domain and its role in cell survival and apoptosis. FEBS J. 2005 Aug;272(16):4091-102. [Content Brief]

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