Ankyrin repeat domain-containing protein 1

Definition:

May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells.

References:

[1]. W Chu, et al. Identification and characterization of a novel cytokine-inducible nuclear protein from human endothelial cells. J Biol Chem. 1995 Apr 28;270(17):10236-45. [Content Brief]

[2]. Jeong-Hyang Park, et al. Identification of the genes involved in enhanced fenretinide-induced apoptosis by parthenolide in human hepatoma cells. Cancer Res. 2005 Apr 1;65(7):2804-14. [Content Brief]

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