AP-1 complex-associated regulatory protein

Definition:

Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex.

References:

[1]. Karine Laulagnier, et al. Role of AP1 and Gadkin in the traffic of secretory endo-lysosomes. Mol Biol Cell. 2011 Jun 15;22(12):2068-82. [Content Brief]

[2]. Veronika E Neubrand, et al. Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking. EMBO J. 2005 Mar 23;24(6):1122-33. [Content Brief]

[3]. Michael R Schmidt, et al. Regulation of endosomal membrane traffic by a Gadkin/AP-1/kinesin KIF5 complex. Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15344-9. [Content Brief]

[4]. Tanja Maritzen, et al. Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10382-7. [Content Brief]

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