AP-4 complex subunit beta-1

Definition:

Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable).

References:

[1]. J Hirst, et al. Characterization of a fourth adaptor-related protein complex. Mol Biol Cell. 1999 Aug;10(8):2787-802. [Content Brief]

[2]. E C Dell'Angelica, et al. AP-4, a novel protein complex related to clathrin adaptors. J Biol Chem. 1999 Mar 12;274(11):7278-85. [Content Brief]

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