Apolipoprotein C-III

Definition:

Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners.

References:

[1]. Chinthaka Saneth Gangabadage, et al. Structure and dynamics of human apolipoprotein CIII. J Biol Chem. 2008 Jun 20;283(25):17416-27. [Content Brief]

[2]. Zemin Yao, et al. Apolipoprotein C-III and hepatic triglyceride-rich lipoprotein production. Curr Opin Lipidol. 2012 Jun;23(3):206-212. [Content Brief]

[3]. D C Chan, et al. An ABC of apolipoprotein C-III: a clinically useful new cardiovascular risk factor?. Int J Clin Pract. 2008 May;62(5):799-809. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.