Apoptosis-resistant E3 ubiquitin protein ligase 1

Definition:

E3 ubiquitin-protein ligase that catalyzes 'Lys-11'- or 'Lys-33'-linked polyubiquitin chains, with some preference for 'Lys-33' linkages. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates SEPTIN4, DIABLO/SMAC and HTRA2 in vitro. Modulates pulmonary inflammation by targeting SOCS2 for ubiquitination and subsequent degradation by the proteasome.

References:

[1]. Travis B Lear, et al. KIAA0317 regulates pulmonary inflammation through SOCS2 degradation. JCI Insight. 2019 Oct 3;4(19):e129110. [Content Brief]

[2]. Martin A Michel, et al. Assembly and specific recognition of k29- and k33-linked polyubiquitin. Mol Cell. 2015 Apr 2;58(1):95-109. [Content Brief]

[3]. Jung-Bin Kim, et al. Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS. J Biol Chem. 2013 Apr 26;288(17):12014-21. [Content Brief]

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