Apurinic endonuclease 1 (APE1)

Definition:

Apurinic endonuclease 1 (APE1) is one of the key enzyme in the DNA base excision repair system. APE1 hydrolyzes DNA adjacent to the 5'-end of an apurinic/apyrimidinic (AP) site to produce a nick with a 3'-hydroxyl group and a 5'-deoxyribose phosphate moiety.

References:

[1]. Dyrkheeva NS, et al. AP Endonuclease 1 as a Key Enzyme in Repair of Apurinic/Apyrimidinic Sites. Biochemistry (Mosc). 2016 Sep;81(9):951-67. [Content Brief]

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