Arachidonate 5-lipoxygenase (5-LOX)

Definition:

Arachidonate 5-lipoxygenase (ALOX5), an immune-responsive metabolic enzyme expressed in neutrophils, macrophages, and dendritic cells, generates lipid mediators (LMs) during post-myocardial infarction healing.

References:

[1]. Ganesh V Halade, et al. Arachidonate 5-lipoxygenase is essential for biosynthesis of specialized pro-resolving mediators and cardiac repair in heart failure. Am J Physiol Heart Circ Physiol. 2022 Oct 1;323(4):H721-H737. [Content Brief]

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