Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1

Definition:

GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.

References:

[1]. Jian Li, et al. An ACAP1-containing clathrin coat complex for endocytic recycling. J Cell Biol. 2007 Jul 30;178(3):453-64. [Content Brief]

[2]. Ming Bai, et al. Mechanistic insights into regulated cargo binding by ACAP1 protein. J Biol Chem. 2012 Aug 17;287(34):28675-85. [Content Brief]

[3]. T R Jackson, et al. ACAPs are arf6 GTPase-activating proteins that function in the cell periphery. J Cell Biol. 2000 Oct 30;151(3):627-38. [Content Brief]

[4]. Zhong Ma, et al. Regulation of Arf6 and ACAP1 signaling by the PTB-domain-containing adaptor protein GULP. Curr Biol. 2007 Apr 17;17(8):722-7. [Content Brief]

[5]. Jian Li, et al. Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of integrin beta1 to control cell migration. Dev Cell. 2005 Nov;9(5):663-73. [Content Brief]

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