Arfaptin-2

Definition:

Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2. Also involved in autophagy by regulating the starvation-dependent trafficking of ATG9A vesicles which deliver the phosphatidylinositol 4-kinase beta (PI4KB) to the autophagosome initiation site. Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria. In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG.

References:

[1]. Delphine Judith, et al. ATG9A supplies PtdIns4P to the autophagosome initiation site. Autophagy. 2019 Sep;15(9):1660-1661. [Content Brief]

[2]. Thanh Ngoc Nguyen, et al. ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system. Mol Cell. 2021 May 6;81(9):2013-2030.e9. [Content Brief]

[3]. Delphine Judith, et al. ATG9A shapes the forming autophagosome through Arfaptin 2 and phosphatidylinositol 4-kinase IIIβ. J Cell Biol. 2019 May 6;218(5):1634-1652. [Content Brief]

[4]. Dong-Joo You, et al. Dimer of arfaptin 2 regulates NF-κB signaling by interacting with IKKβ/NEMO and inhibiting IKKβ kinase activity. Cell Signal. 2015 Nov;27(11):2173-81. [Content Brief]

[5]. Tim Eiseler, et al. Protein Kinase D2 Assembles a Multiprotein Complex at the Trans-Golgi Network to Regulate Matrix Metalloproteinase Secretion. J Biol Chem. 2016 Jan 1;291(1):462-77. [Content Brief]

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