Arginine--tRNA ligase, cytoplasmic

Definition:

Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1.

References:

[1]. Arianna Bottoni, et al. Proteasomes and RARS modulate AIMP1/EMAP II secretion in human cancer cell lines. J Cell Physiol. 2007 Aug;212(2):293-7. [Content Brief]

[2]. Yaoyao Fu, et al. Structure of the ArgRS-GlnRS-AIMP1 complex and its implications for mammalian translation. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15084-9. [Content Brief]

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