Arylsulfatase G

Definition:

Displays arylsulfatase activity at acidic pH towards artificial substrates, such as p-nitrocatechol sulfate and also, but with a lower activity towards p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate. Catalyzes the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin.

References:

[1]. Marc-André Frese, et al. Arylsulfatase G, a novel lysosomal sulfatase. J Biol Chem. 2008 Apr 25;283(17):11388-95. [Content Brief]

[2]. Samer Khateb, et al. A homozygous founder missense variant in arylsulfatase G abolishes its enzymatic activity causing atypical Usher syndrome in humans. Genet Med. 2018 Sep;20(9):1004-1012. [Content Brief]

[3]. Björn Kowalewski, et al. Arylsulfatase G inactivation causes loss of heparan sulfate 3-O-sulfatase activity and mucopolysaccharidosis in mice. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10310-5. [Content Brief]

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