Ataxin-7

Definition:

Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization.

References:

[1]. Yoko Nakamura, et al. Ataxin-7 associates with microtubules and stabilizes the cytoskeletal network. Hum Mol Genet. 2012 Mar 1;21(5):1099-110. [Content Brief]

[2]. Vikas B Palhan, et al. Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8472-7. [Content Brief]

[3]. Yue Zhao, et al. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. Mol Cell. 2008 Jan 18;29(1):92-101. [Content Brief]

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