ATP-binding cassette sub-family B member 5

Definition:

Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair (By similarity).

References:

[1]. Natasha Y Frank, et al. ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. Cancer Res. 2005 May 15;65(10):4320-33. [Content Brief]

[2]. Takaaki Kawanobe, et al. Expression of human ABCB5 confers resistance to taxanes and anthracyclines. Biochem Biophys Res Commun. 2012 Feb 24;418(4):736-41. [Content Brief]

[3]. Ying Huang, et al. Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance. Cancer Res. 2004 Jun 15;64(12):4294-301. [Content Brief]

[4]. Natasha Y Frank, et al. Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter. J Biol Chem. 2003 Nov 21;278(47):47156-65. [Content Brief]

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