ATP-binding cassette sub-family G member 5

Definition:

ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Required for normal sterol homeostasis. The heterodimer with ABCG8 has ATPase activity.

References:

[1]. G Schmitz, et al. Role of ABCG1 and other ABCG family members in lipid metabolism. J Lipid Res. 2001 Oct;42(10):1513-20. [Content Brief]

[2]. Jyh-Yeuan Lee, et al. Crystal structure of the human sterol transporter ABCG5/ABCG8. Nature. 2016 May 26;533(7604):561-4. [Content Brief]

[3]. M H Lee, et al. Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption. Nat Genet. 2001 Jan;27(1):79-83. [Content Brief]

[4]. Gregory A Graf, et al. Missense mutations in ABCG5 and ABCG8 disrupt heterodimerization and trafficking. J Biol Chem. 2004 Jun 4;279(23):24881-8. [Content Brief]

[5]. Zhanling Wang, et al. Purification and ATP hydrolysis of the putative cholesterol transporters ABCG5 and ABCG8. Biochemistry. 2006 Aug 15;45(32):9929-39. [Content Brief]

[6]. Brandy J Harvey Johnson, et al. Bile acids stimulate ATP hydrolysis in the purified cholesterol transporter ABCG5/G8. Biochemistry. 2010 Apr 27;49(16):3403-11. [Content Brief]

[7]. K E Berge, et al. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science. 2000 Dec 1;290(5497):1771-5. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.