ATP-dependent RNA helicase DHX33

Definition:

Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing (By similarity). Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation. Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells. Required for NLRP3 activation induced by viral dsRNA and bacterial RNA. In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF-kappa-B signaling pathways (By similarity).

References:

[1]. Yandong Zhang, et al. The DHX33 RNA Helicase Promotes mRNA Translation Initiation. Mol Cell Biol. 2015 Sep 1;35(17):2918-31. [Content Brief]

[2]. Yandong Zhang, et al. Identification of DHX33 as a mediator of rRNA synthesis and cell growth. Mol Cell Biol. 2011 Dec;31(23):4676-91. [Content Brief]

[3]. Hiroki Mitoma, et al. The DHX33 RNA helicase senses cytosolic RNA and activates the NLRP3 inflammasome. Immunity. 2013 Jul 25;39(1):123-35. [Content Brief]

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