ATP-sensitive inward rectifier potassium channel 12

Definition:

Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

References:

[1]. N Namba, et al. Kir2.2v: a possible negative regulator of the inwardly rectifying K+ channel Kir2.2. FEBS Lett. 1996 May 20;386(2-3):211-4. [Content Brief]

[2]. B A Wible, et al. Cloning and functional expression of an inwardly rectifying K+ channel from human atrium. Circ Res. 1995 Mar;76(3):343-50. [Content Brief]

[3]. Nazzareno D'Avanzo, et al. Direct and specific activation of human inward rectifier K+ channels by membrane phosphatidylinositol 4,5-bisphosphate. J Biol Chem. 2010 Nov 26;285(48):37129-32. [Content Brief]

[4]. Muneshige Kaibara, et al. Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes. FEBS Lett. 2002 Nov 6;531(2):250-4. [Content Brief]

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