Atrial natriuretic peptide-converting enzyme

Definition:

Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing. Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney (By similarity).; [Isoform 2]: Has weaker endopeptidase activity compared to isoform 1.

References:

[1]. Jingjing Jiang, et al. Ectodomain shedding and autocleavage of the cardiac membrane protease corin. J Biol Chem. 2011 Mar 25;286(12):10066-72. [Content Brief]

[2]. Yujie Cui, et al. Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy. Nature. 2012 Mar 21;484(7393):246-50. [Content Brief]

[3]. Alexander G Semenov, et al. Processing of pro-B-type natriuretic peptide: furin and corin as candidate convertases. Clin Chem. 2010 Jul;56(7):1166-76. [Content Brief]

[4]. Jianhao Peng, et al. Glycosylation and processing of pro-B-type natriuretic peptide in cardiomyocytes. Biochem Biophys Res Commun. 2011 Aug 5;411(3):593-8. [Content Brief]

[5]. W Yan, et al. Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8525-9. [Content Brief]

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