Atrial natriuretic peptide receptor 2

Definition:

Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.

References:

[1]. K J Koller, et al. Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP). Science. 1991 Apr 5;252(5002):120-3. [Content Brief]

[2]. Naoko Amano, et al. Identification and functional characterization of two novel NPR2 mutations in Japanese patients with short stature. J Clin Endocrinol Metab. 2014 Apr;99(4):E713-8. [Content Brief]

[3]. Cynthia F Bartels, et al. Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux. Am J Hum Genet. 2004 Jul;75(1):27-34. [Content Brief]

[4]. Deborah M Dickey, et al. Catalytically Active Guanylyl Cyclase B Requires Endoplasmic Reticulum-mediated Glycosylation, and Mutations That Inhibit This Process Cause Dwarfism. J Biol Chem. 2016 May 20;291(21):11385-93. [Content Brief]

[5]. Gabriela A Vasques, et al. Heterozygous mutations in natriuretic peptide receptor-B (NPR2) gene as a cause of short stature in patients initially classified as idiopathic short stature. J Clin Endocrinol Metab. 2013 Oct;98(10):E1636-44. [Content Brief]

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