Aurora kinase C

Definition:

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.

References:

[1]. Xiaomei Yan, et al. Aurora C is directly associated with Survivin and required for cytokinesis. Genes Cells. 2005 Jun;10(6):617-26. [Content Brief]

[2]. Xiaomei Yan, et al. Cloning and characterization of a novel human Aurora C splicing variant. Biochem Biophys Res Commun. 2005 Mar 4;328(1):353-61. [Content Brief]

[3]. Margarida Avo Santos, et al. A role for Aurora C in the chromosomal passenger complex during human preimplantation embryo development. Hum Reprod. 2011 Jul;26(7):1868-81. [Content Brief]

[4]. Jean-Charles Gabillard, et al. Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein. Biochem Biophys Res Commun. 2011 May 20;408(4):647-53. [Content Brief]

[5]. Xiangyu Li, et al. Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C. J Biol Chem. 2004 Nov 5;279(45):47201-11. [Content Brief]

[6]. Kaori Sasai, et al. Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. Cell Motil Cytoskeleton. 2004 Dec;59(4):249-63. [Content Brief]

[7]. Kaori Sasai, et al. Aurora-C Interactions with Survivin and INCENP Reveal Shared and Distinct Features Compared with Aurora-B Chromosome Passenger Protein Complex. PLoS One. 2016 Jun 22;11(6):e0157305. [Content Brief]

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