Bimolecular Luminescence Complementation

Definition:

The bimolecular luminescence complementation (BiLC) is an assay for determination of protein interactions and/or their location in living cells. This approach is based on complementation between two fragments of a bioluminescent enzyme such as luciferin or aequorin. Interactions between proteins fused to each fragment bring the fragments together resulting in the reconstitution of a fully functional bioluminescent enzyme that can be identified through microscopy or luminescence detection.

References:

[1]. Ontobee, Molecular Interactions Controlled Vocabulary, MI_2170, Bimolecular Luminescence Complementation.

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