C-type lectin domain family 1 member B

Definition:

C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN. After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2.; (Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2.; (Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets.

References:

[1]. Charita M Christou, et al. Renal cells activate the platelet receptor CLEC-2 through podoplanin. Biochem J. 2008 Apr 1;411(1):133-40. [Content Brief]

[2]. Chawaree Chaipan, et al. DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets. J Virol. 2006 Sep;80(18):8951-60. [Content Brief]

[3]. Jun Mori, et al. G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2. J Biol Chem. 2008 Dec 19;283(51):35419-27. [Content Brief]

[4]. Katsue Suzuki-Inoue, et al. A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. Blood. 2006 Jan 15;107(2):542-9. [Content Brief]

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