Catenin delta-1

Definition:

Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors.

References:

[1]. Michael A Davis, et al. A core function for p120-catenin in cadherin turnover. J Cell Biol. 2003 Nov 10;163(3):525-34. [Content Brief]

[2]. Catherine Rose Hosking, et al. The transcriptional repressor Glis2 is a novel binding partner for p120 catenin. Mol Biol Cell. 2007 May;18(5):1918-27. [Content Brief]

[3]. J M Daniel, et al. The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. Mol Cell Biol. 1999 May;19(5):3614-23. [Content Brief]

[4]. Noboru Ishiyama, et al. Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion. Cell. 2010 Apr 2;141(1):117-28. [Content Brief]

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