CD276 antigen

Definition:

May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

References:

[1]. Liqing Wang, et al. B7-H3 promotes acute and chronic allograft rejection. Eur J Immunol. 2005 Feb;35(2):428-38. [Content Brief]

[2]. A I Chapoval, et al. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat Immunol. 2001 Mar;2(3):269-74. [Content Brief]

[3]. Jean Kim, et al. Constitutive and inducible expression of b7 family of ligands by human airway epithelial cells. Am J Respir Cell Mol Biol. 2005 Sep;33(3):280-9. [Content Brief]

[4]. Peter Steinberger, et al. Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains. J Immunol. 2004 Feb 15;172(4):2352-9. [Content Brief]

[5]. Vincent Ling, et al. Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss. Genomics. 2003 Sep;82(3):365-77. [Content Brief]

[6]. Roberta Castriconi, et al. Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12640-5. [Content Brief]

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