CDK5 regulatory subunit-associated protein 2

Definition:

Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes. In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery. Required for the recruitment of AKAP9 to centrosomes. Plays a role in neurogenesis (By similarity).

References:

[1]. Xiaoying Zhang, et al. CDK5RAP2 is required for spindle checkpoint function. Cell Cycle. 2009 Apr 15;8(8):1206-16. [Content Brief]

[2]. Susanne Graser, et al. Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion. J Cell Sci. 2007 Dec 15;120(Pt 24):4321-31. [Content Brief]

[3]. Ka-Wing Fong, et al. Interaction of CDK5RAP2 with EB1 to track growing microtubule tips and to regulate microtubule dynamics. Mol Biol Cell. 2009 Aug;20(16):3660-70. [Content Brief]

[4]. Habib Bouguenina, et al. EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions. Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10687-E10696. [Content Brief]

[5]. Ka-Wing Fong, et al. CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex. Mol Biol Cell. 2008 Jan;19(1):115-25. [Content Brief]

[6]. Yusuke Mori, et al. Cep169, a Novel Microtubule Plus-End-Tracking Centrosomal Protein, Binds to CDK5RAP2 and Regulates Microtubule Stability. PLoS One. 2015 Oct 20;10(10):e0140968. [Content Brief]

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