Celiac disease

Definition:

Celiac disease is a chronic gluten intolerance that occurs in genetically predisposed individuals. The ingestion of gluten causes chronic inflammation of the small intestinal mucosa, leading to nutrient malabsorption. Susceptibility to celiac disease is strongly associated with particular HLA class II alleles. However, non-HLA genetic factors are likely to be required for the development of the disease. It has been reported that CTLA4 and MYO9B gene polymorphisms are associated with predisposition to celiac disease.

References:

[1]. Alienke J Monsuur, et al. Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. Nat Genet. 2005 Dec;37(12):1341-4. [Content Brief]

[2]. Francesca Megiorni, et al. HLA-DQA1 and HLA-DQB1 in Celiac disease predisposition: practical implications of the HLA molecular typing. J Biomed Sci. 2012 Oct 11;19(1):88. [Content Brief]

[3]. I Djilali-Saiah, et al. CTLA-4 gene polymorphism is associated with predisposition to coeliac disease. Gut. 1998 Aug;43(2):187-9. [Content Brief]

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