Centrosomal protein of 135 kDa

Definition:

Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner.

References:

[1]. Julia Kleylein-Sohn, et al. Plk4-induced centriole biogenesis in human cells. Dev Cell. 2007 Aug;13(2):190-202. [Content Brief]

[2]. Ching-Wen Chang, et al. CEP295 interacts with microtubules and is required for centriole elongation. J Cell Sci. 2016 Jul 1;129(13):2501-13. [Content Brief]

[3]. Kyeongmi Kim, et al. A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization. Exp Cell Res. 2008 Dec 10;314(20):3692-700. [Content Brief]

[4]. Bahtiyar Kurtulmus, et al. WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis. J Cell Sci. 2016 Feb 1;129(3):621-36. [Content Brief]

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