Cilia- and flagella-associated protein 53

Definition:

Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis.

References:

[1]. Emily S Noël, et al. A Zebrafish Loss-of-Function Model for Human CFAP53 Mutations Reveals Its Specific Role in Laterality Organ Function. Hum Mutat. 2016 Feb;37(2):194-200. [Content Brief]

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