Circulating Tumor Cell（CTC）

Definition:

In 1869, Ashworth first proposed the concept of circulating tumor cells.Afterwards, it was supplemented and revised by Nowell: originating from the primary tumor or metastatic tumor, gaining the ability to break away from the basement membrane and invade tumor cells that enter blood vessels through the tissue matrix.At present, it mainly refers to various tumor cells existing in peripheral blood.

References:

[1]. Ignatiadis M, et al. Circulating tumor cells and circulating tumor DNA for precision medicine: dream or reality? Ann Oncol. 2014;25(12):2304-2313. [Content Brief]

[2]. Liu X, et al. Immune checkpoint HLA-E:CD94-NKG2A mediates evasion of circulating tumor cells from NK cell surveillance. Cancer Cell. 2023;41(2):272-287.e9. [Content Brief]

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