COMM domain-containing protein 1

Definition:

Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Involved in the regulation of membrane expression and ubiquitination of SLC12A2. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes. Promotes CFTR cell surface expression through regulation of its ubiquitination. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1. Negatively regulates neuroblastoma G1/S phase cell cycle progression and cell proliferation by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a FAM107A- and actin-dependent manner.

References:

[1]. Loïc Drévillon, et al. COMMD1-mediated ubiquitination regulates CFTR trafficking. PLoS One. 2011 Mar 31;6(3):e18334. [Content Brief]

[2]. Ezra Burstein, et al. A novel role for XIAP in copper homeostasis through regulation of MURR1. EMBO J. 2004 Jan 14;23(1):244-54. [Content Brief]

[3]. Prim de Bie, et al. Characterization of COMMD protein-protein interactions in NF-kappaB signalling. Biochem J. 2006 Aug 15;398(1):63-71. [Content Brief]

[4]. Ying Ke, et al. COMMD1 downregulates the epithelial sodium channel through Nedd4-2. Am J Physiol Renal Physiol. 2010 Jun;298(6):F1445-56. [Content Brief]

[5]. Hazel C Thoms, et al. Nucleolar targeting of RelA(p65) is regulated by COMMD1-dependent ubiquitination. Cancer Res. 2010 Jan 1;70(1):139-49. [Content Brief]

[6]. Ezra Burstein, et al. COMMD proteins, a novel family of structural and functional homologs of MURR1. J Biol Chem. 2005 Jun 10;280(23):22222-32. [Content Brief]

[7]. Suree Narindrasorasak, et al. Characterization and copper binding properties of human COMMD1 (MURR1). Biochemistry. 2007 Mar 20;46(11):3116-28. [Content Brief]

[8]. Willianne I M Vonk, et al. Cu,Zn superoxide dismutase maturation and activity are regulated by COMMD1. J Biol Chem. 2010 Sep 10;285(37):28991-9000. [Content Brief]

[9]. Wolfgang Biasio, et al. Identification of Murr1 as a regulator of the human delta epithelial sodium channel. J Biol Chem. 2004 Feb 13;279(7):5429-34. [Content Brief]

[10]. Bart van de Sluis, et al. COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion. J Clin Invest. 2010 Jun;120(6):2119-30. [Content Brief]

[11]. Gabriel N Maine, et al. COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase. EMBO J. 2007 Jan 24;26(2):436-47. [Content Brief]

[12]. Tina Chang, et al. COMMD1 regulates the delta epithelial sodium channel (δENaC) through trafficking and ubiquitination. Biochem Biophys Res Commun. 2011 Aug 5;411(3):506-11. [Content Brief]

[13]. P Mu, et al. A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-κB degradation and cell growth suppression in neuroblastoma. Oncogene. 2017 Oct 12;36(41):5745-5756. [Content Brief]

[14]. Christine A Phillips-Krawczak, et al. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. Mol Biol Cell. 2015 Jan 1;26(1):91-103. [Content Brief]

[15]. Laura Smith, et al. COMMD1 interacts with the COOH terminus of NKCC1 in Calu-3 airway epithelial cells to modulate NKCC1 ubiquitination. Am J Physiol Cell Physiol. 2013 Jul 15;305(2):C133-46. [Content Brief]

[16]. Jason L Burkhead, et al. COMMD1 forms oligomeric complexes targeted to the endocytic membranes via specific interactions with phosphatidylinositol 4,5-bisphosphate. J Biol Chem. 2009 Jan 2;284(1):696-707. [Content Brief]

[17]. Xicheng Mao, et al. COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. J Biol Chem. 2011 Sep 16;286(37):32355-65. [Content Brief]

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