Cyclic AMP-dependent transcription factor ATF-3

Definition:

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter.; [Isoform 2]: Activates transcription presumably by sequestering inhibitory cofactors away from the promoters.; [Isoform 3]: Stress-induced isoform, counteracts the transcriptional repression of isoform 1.

References:

[1]. B P Chen, et al. ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms. J Biol Chem. 1994 Jun 3;269(22):15819-26. [Content Brief]

[2]. Yoshinori Hashimoto, et al. An alternatively spliced isoform of transcriptional repressor ATF3 and its induction by stress stimuli. Nucleic Acids Res. 2002 Jun 1;30(11):2398-406. [Content Brief]

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