Cyclin-dependent kinase 2-interacting protein

Definition:

Component of the DNA replication complex, which interacts with two kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling in response to DNA damage. Also involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles. Promotes maturation of pre-60S ribosome together with SPATA5, SPATA5L1 and C1orf109.

References:

[1]. Courtney A Lovejoy, et al. Functional genomic screens identify CINP as a genome maintenance protein. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19304-9. [Content Brief]

[2]. Irina Grishina, et al. A novel Cdk2 interactor is phosphorylated by Cdc7 and associates with components of the replication complexes. Cell Cycle. 2005 Aug;4(8):1120-6. [Content Brief]

[3]. Chunyang Ni, et al. Labeling of heterochronic ribosomes reveals C1ORF109 and SPATA5 control a late step in human ribosome assembly. Cell Rep. 2022 Mar 29;38(13):110597. [Content Brief]

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