Delta

Definition:

Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.

References:

[1]. Pei-Ling Tsai, et al. The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations. Elife. 2016 Jun 23;5:e16011. [Content Brief]

[2]. Winnie Luu, et al. The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally. J Lipid Res. 2015 Apr;56(4):888-97. [Content Brief]

[3]. S Silve, et al. Human lamin B receptor exhibits sterol C14-reductase activity in Saccharomyces cerevisiae. Biochim Biophys Acta. 1998 Jun 15;1392(2-3):233-44. [Content Brief]

[4]. Xiuli Lu, et al. The membrane topological analysis of 3β-hydroxysteroid-Delta24 reductase (DHCR24) on endoplasmic reticulum. J Mol Endocrinol. 2012 Jan 25;48(1):1-9. [Content Brief]

[5]. Christian P Schaaf, et al. Desmosterolosis-phenotypic and molecular characterization of a third case and review of the literature. Am J Med Genet A. 2011 Jul;155A(7):1597-604. [Content Brief]

[6]. Eser J Zerenturk, et al. The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1). Biochim Biophys Acta. 2012 Sep;1821(9):1269-77. [Content Brief]

[7]. I Duband-Goulet, et al. Inner nuclear membrane protein LBR preferentially interacts with DNA secondary structures and nucleosomal linker. Biochemistry. 2000 May 30;39(21):6483-8. [Content Brief]

[8]. I Greeve, et al. The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress. J Neurosci. 2000 Oct 1;20(19):7345-52. [Content Brief]

[9]. Peter Clayton, et al. Mutations causing Greenberg dysplasia but not Pelger anomaly uncouple enzymatic from structural functions of a nuclear membrane protein. Nucleus. 2010 Jul-Aug;1(4):354-66. [Content Brief]

[10]. H R Waterham, et al. Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis. Am J Hum Genet. 2001 Oct;69(4):685-94. [Content Brief]

[11]. Hans R Waterham, et al. Autosomal recessive HEM/Greenberg skeletal dysplasia is caused by 3 beta-hydroxysterol delta 14-reductase deficiency due to mutations in the lamin B receptor gene. Am J Hum Genet. 2003 Apr;72(4):1013-7. [Content Brief]

[12]. Anna Maria Bennati, et al. Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis. Biochim Biophys Acta. 2006 Jul;1761(7):677-85. [Content Brief]

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