Dermatitis herpetiformis

Definition:

Dermatitis herpetiformis (DH) is a chronic, polymorphic, pruritic skin disease that develops mostly in patients with latent gluten-sensitive enteropathy. There is an association with the genotypes HLA DR3, HLA DQw2, found in 80-90% of cases. Owing to the granular immunoglobulin (Ig) A deposition at the tips of the papillary dermis and to the subepidermal blister formation associated with neutrophilic accumulations underlying the basement membrane, DH is considered to be an autoimmune blistering disease.

References:

[1]. Diana Bolotin, et al. Dermatitis herpetiformis. Part II. Diagnosis, management, and prognosis. J Am Acad Dermatol. 2011 Jun;64(6):1027-33; quiz 1033-4. [Content Brief]

[2]. Fernanda Berti Rocha Mendes, et al. Review: dermatitis herpetiformis. An Bras Dermatol. 2013 Jul-Aug;88(4):594-9. [Content Brief]

[3]. Kimiko Nakajima, et al. Recent advances in dermatitis herpetiformis. Clin Dev Immunol. 2012;2012:914162. [Content Brief]

[4]. M Caproni, et al. Guidelines for the diagnosis and treatment of dermatitis herpetiformis. J Eur Acad Dermatol Venereol. 2009 Jun;23(6):633-8. [Content Brief]

[5]. Sarolta Kárpáti, et al. Dermatitis herpetiformis. Clin Dermatol. 2012 Jan-Feb;30(1):56-9. [Content Brief]

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