Developmentally-regulated GTP-binding protein 1

Definition:

Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions.

References:

[1]. Isabel Pérez-Arellano, et al. Human Drg1 is a potassium-dependent GTPase enhanced by Lerepo4. FEBS J. 2013 Aug;280(15):3647-57. [Content Brief]

[2]. Suzana Markolovic, et al. The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases. Nat Chem Biol. 2018 Jul;14(7):688-695. [Content Brief]

[3]. Anna Katharina Schellhaus, et al. Developmentally Regulated GTP binding protein 1 (DRG1) controls microtubule dynamics. Sci Rep. 2017 Aug 30;7(1):9996. [Content Brief]

[4]. Kosuke Ishikawa, et al. Independent stabilizations of polysomal Drg1/Dfrp1 complex and non-polysomal Drg2/Dfrp2 complex in mammalian cells. Biochem Biophys Res Commun. 2009 Dec 18;390(3):552-6. [Content Brief]

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