DIS3-like exonuclease 1

Definition:

Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.

References:

[1]. Raymond H J Staals, et al. Dis3-like 1: a novel exoribonuclease associated with the human exosome. EMBO J. 2010 Jul 21;29(14):2358-67. [Content Brief]

[2]. Rafal Tomecki, et al. The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. EMBO J. 2010 Jul 21;29(14):2342-57. [Content Brief]

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