DNA ligase 3

Definition:

Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair.

References:

[1]. U Lakshmipathy, et al. The human DNA ligase III gene encodes nuclear and mitochondrial proteins. Mol Cell Biol. 1999 May;19(5):3869-76. [Content Brief]

[2]. Mansour Akbari, et al. Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair. DNA Repair (Amst). 2014 Apr;16:44-53. [Content Brief]

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