DNA/RNA-binding protein KIN17

Definition:

Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro.

References:

[1]. Denis S F Biard, et al. Ionizing radiation triggers chromatin-bound kin17 complex formation in human cells. J Biol Chem. 2002 May 24;277(21):19156-65. [Content Brief]

[2]. Laurent Miccoli, et al. Human kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication. Cancer Res. 2002 Oct 1;62(19):5425-35. [Content Brief]

[3]. Albane le Maire, et al. A tandem of SH3-like domains participates in RNA binding in KIN17, a human protein activated in response to genotoxics. J Mol Biol. 2006 Dec 8;364(4):764-76. [Content Brief]

[4]. Denis S F Biard, et al. Participation of kin17 protein in replication factories and in other DNA transactions mediated by high molecular weight nuclear complexes. Mol Cancer Res. 2003 May;1(7):519-31. [Content Brief]

[5]. Laurent Miccoli, et al. Selective interactions of human kin17 and RPA proteins with chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner. Nucleic Acids Res. 2003 Jul 15;31(14):4162-75. [Content Brief]

[6]. Laurent Miccoli, et al. The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins. Mol Cell Biol. 2005 May;25(9):3814-30. [Content Brief]

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