Dynein axonemal assembly factor 11

Definition:

Involved in dynein arm assembly, is important for expression and transporting outer dynein arm (ODA) proteins from the cytoplasm to the cilia. Acts as a crucial component in the formation and motility of spermatozoal flagella.

References:

[1]. Amjad Horani, et al. LRRC6 mutation causes primary ciliary dyskinesia with dynein arm defects. PLoS One. 2013;8(3):e59436. [Content Brief]

[2]. Yaqian Li, et al. The effect of a novel LRRC6 mutation on the flagellar ultrastructure in a primary ciliary dyskinesia patient. J Assist Reprod Genet. 2021 Mar;38(3):689-696. [Content Brief]

[3]. Esther Kott, et al. Loss-of-function mutations in LRRC6, a gene essential for proper axonemal assembly of inner and outer dynein arms, cause primary ciliary dyskinesia. Am J Hum Genet. 2012 Nov 2;91(5):958-64. [Content Brief]

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