Dystroglycan 1

Definition:

The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.; [Alpha-dystroglycan]: Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for laminin LAMA5 (By similarity).; [Beta-dystroglycan]: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.; [Alpha-dystroglycan]: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus glycoprotein and class C new-world arenaviruses. Acts as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy, but only in the presence of the G-domain of LAMA2.

References:

[1]. A Rambukkana, et al. Role of alpha-dystroglycan as a Schwann cell receptor for Mycobacterium leprae. Science. 1998 Dec 11;282(5396):2076-9. [Content Brief]

[2]. Stefan Kunz, et al. Receptor binding and cell entry of Old World arenaviruses reveal novel aspects of virus-host interaction. Virology. 2009 May 10;387(2):245-9. [Content Brief]

[3]. Mauro Imperiali, et al. O Mannosylation of alpha-dystroglycan is essential for lymphocytic choriomeningitis virus receptor function. J Virol. 2005 Nov;79(22):14297-308. [Content Brief]

[4]. Jillian M Rojek, et al. Old World and clade C New World arenaviruses mimic the molecular mechanism of receptor recognition used by alpha-dystroglycan's host-derived ligands. J Virol. 2007 Jun;81(11):5685-95. [Content Brief]

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